| Biological activity | Acivicin hydrochloride (AT-125 hydrochloride) is a natural product produced by Streptomyces suis and is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin hydrochloride can penetrate the blood-brain barrier and have anti-cancer and anti-parasitic properties. |
| Target | γ-glutamyl transpeptidase |
| in vitro study | Acivicin hydrochloride (AT-125 hydrochloride; 0.1-50 μM; 5 days) has an IC 50 of 0.7 μM in human HepG2 cells. |
| in vivo study | Acivicin hydrochloride (AT-125 hydrochloride; 5 mg/kg; IP; Wice weekly) reduces urinary γ-GT by 70-78%. Animal Model: Male pigmented Long-Evans rats weighed between 250 g and 300 g exposed to Toluene Dosage: 5 mg/kg Administration: IP; Wice weekly (Monday and Wednesday) Result: reduced urinary γ-GT by 70-78%. |
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Animal Model:
| Male pigmented Long-Evans rats weighed between 250 g and 300 g exposed to Toluene |
|
Dosage:
| 5 mg/kg |
|
Administration:
| IP; twice weekly (monday and wednesday) |
|
Result:
| Reduced urinary γ-GT by 70-78%. |
